منابع مشابه
Airway clearance in cystic fibrosis.
Airway clearance is considered an integral component of standard therapy for cystic fibrosis (CF) patients. Although the pathophysiology of CF has not been conclusively delineated, most of the theories revolve around the development of viscous airway secretions.1–4 These secretions are thought to be poorly cleared from the lung, leading to airway obstruction and infection with Staphylococcus au...
متن کاملCYSTIC FIBROSIS Airway remodelling in children with cystic fibrosis
Background: The relationship between airway structural changes and inflammation is unclear in early cystic fibrosis (CF) lung disease. A study was undertaken to determine changes in airway remodelling in children with CF compared with appropriate disease and healthy controls. Methods: Bronchoalveolar lavage and endobronchial biopsy were performed in a cross-sectional study of 43 children with C...
متن کاملThe cystic fibrosis airway microbiome.
Repeated pulmonary exacerbation and progressive lung function decline characterize cystic fibrosis (CF) disease, and represents one of the leading causes of mortality in this patient population. Recent studies have shown, using culture-independent assays, that multiple microbial species can be detected in airway samples from CF patients. Moreover, specific groups of bacteria within these bacter...
متن کاملMature Cystic Fibrosis Airway Neutrophils
Bacteria colonize cystic fibrosis (CF) airways, and although T cells with appropriate Ag specificity are present in draining lymph nodes, they are conspicuously absent from the lumen. To account for this absence, we hypothesized that polymorphonuclear neu-trophils (PMNs), recruited massively into the CF airway lumen and actively exocytosing primary granules, also suppress T cell function therei...
متن کاملAirway remodelling in children with cystic fibrosis.
BACKGROUND The relationship between airway structural changes and inflammation is unclear in early cystic fibrosis (CF) lung disease. A study was undertaken to determine changes in airway remodelling in children with CF compared with appropriate disease and healthy controls. METHODS Bronchoalveolar lavage and endobronchial biopsy were performed in a cross-sectional study of 43 children with C...
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ژورنال
عنوان ژورنال: Journal of Cystic Fibrosis
سال: 2006
ISSN: 1569-1993
DOI: 10.1016/s1569-1993(06)80196-7